Biomarkers play a vital role in disease detection and subsequent treatments. Biomarkers are often measured and evaluated to examine normal biological processes, pathogenic processes, or pharmacologic responses following a therapeutic intervention. Biomarkers are used in many scientific fields such as medicine, geology and astrobiology, cell biology, ecotoxicology, and others. These substances are mainly utilized with the help of specific methodologies, which together constitute the biomarker detection systems. As each of the fields described here are undergoing rampant advancement, the use of biomarker systems has shot up splendidly in recent times.